Rosalie has had enough of "family life", in other words of Georges, her weak husband, and of her cantankerous mother-in-law. One day she decides to hit the road, not knowing where she is going. Joséphine is fed up with... being fed up with life. One day she decides to say no to cancer and depression and she hits the road. Her goal is to join her daughter Carole with whom she has been at odds for ten years. Rosalie and Joséphine, the two confused women meet, journey together, help each other and little by little become inseparable friends.
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